Experimental and clinical studies have shown that an excess rate of fatty acid metabolism impairs the recovery of mechanical function of the post - ischemic heart. Consequently, agents that reduce fatty acid oxidation are beneficial and reduce ischemia - induced injury.

In contrast, stimulation of rates of glucose oxidation is beneficial and improves post ischemia mechanical function.

MMRL has identified a number of pathways and targets that are involved in the regulation of fatty acid and carbohydrate metabolism.
Moreover, MMRL has shown that drug - induced inhibition of excessive rates of fatty acid oxidation and/or stimulation of carbohydrate oxidation will elicit beneficial alterations in overall myocardial metabolism and mechanical function.

Specific details of MMRL technology, drug targets and lead compounds may be made available following execution of appropriate confidentiality agreements.

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