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Experimental and clinical studies have shown that an excess rate of fatty acid metabolism impairs the recovery of mechanical function of the post - ischemic heart. Consequently, agents that reduce fatty acid oxidation are beneficial and reduce ischemia - induced injury.

In contrast, stimulation of rates of glucose oxidation is beneficial and improves post ischemia mechanical function.

MMRL has identified a number of pathways and targets that are involved in the regulation of fatty acid and carbohydrate metabolism.
Moreover, MMRL has shown that drug - induced inhibition of excessive rates of fatty acid oxidation and/or stimulation of carbohydrate oxidation will elicit beneficial alterations in overall myocardial metabolism and mechanical function.

Note:
Specific details of MMRL technology, drug targets and lead compounds may be made available following execution of appropriate confidentiality agreements.


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